Nanocrystals for Improving Oral Bioavailability of Drugs: Intestinal Transport Mechanisms and Influencing Factors

With the limitation of solubility and dissolution rate insoluble drugs, following oral administration, they would rifely prove poor volatile bioavailability, which may fail to realize its therapeutic value. The drug nanocrystals are perceived as effective tactic for administration drugs attributes possess many prominent properties such elevating saturation solubility, high loading capacity, improving bioavailability. Based on these advantages, application in delivery has acquired significant achievement, so far more than 20 products have been confirmed market. However, absorption is still facing huge challenges due factors. Intrinsic complex physiological environment intestinal tract two most important factors affecting bioavailability drugs. In addition, research multi-aspect mechanisms promoting gastrointestinal gradually deepened. this review, we summarized recent advances delivered orally, provided an overview progress crossing transport by some new techniques. Meanwhile, relevant were also elaborated detail.